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Aumento da express？o do MCP-1 coroidal e escleral em modelo experimental de hipercolesterolemia
Torres, Rogil José de Almeida;Noronha, Lucia de;Casella, Antonio Marcelo Barbante;Lumikoski, Thaís Isabel;Précoma, Leonardo Brand？o;Torres, Caroline Luzia de Almeida;Luchini, Andréa;Sturzeneker, Mario Claudio Soares;Précoma, Dalton Bertolim;
Arquivos Brasileiros de Oftalmologia , 2012, DOI: 10.1590/S0004-27492012000100010
Abstract: purpose: the aim of this study is to experientially demonstrate that a cholesterol-enriched diet induces an increase in the mcp-1 expression in the choroid and sclera. method: new zealand rabbits were divided into two groups: gn (normal diet group) of 8 rabbits (8 eyes) was fed a standard rabbit diet for 4 weeks; gh (hypercholesterolemic group) of 13 rabbits (13 eyes) was fed a 1% cholesterol enriched diet for 8 weeks. total serum cholesterol, triglyceride, hdl cholesterol and fasting blood glucose exams were performed at the start of the experiment and at the euthanasia time. after gh 8th week and gn 4th week animals were euthanized and their eyes underwent immunohistochemical analysis with the anti-mcp-1 antibody. results: the diet has induced a significant increase in gh total cholesterol and triglyceride levels when compared with ng (p<0.001). there was a significant increase in the mcp-1 expression in gh choroid and sclera in relation to gn (p<0.001). conclusion: this study has revealed that the hypercholesterolemic diet in rabbits induces an increase in the mcp-1 expression in the choroid and sclera.
Retinopatia solar após ritual religioso na cidade de Londrina
Sampaio, Elaine Regina Ferraresi;Casella, Antonio Marcelo Barbante;Farah, Michel Eid;
Arquivos Brasileiros de Oftalmologia , 2004, DOI: 10.1590/S0004-27492004000200016
Abstract: purpose: to present a series of patients with solar retinopathy after direct solar observation during a religious ritual in londrina city, paraná, brazil. methods: 24 patients with visual alterations were evaluated after their participation in a religious ritual. data of the initial and final visit after 6 months of follow-up are presented and include best corrected visual acuity, refraction, color fundus picture, macular biomicroscopy, amsler's screen and contrast sensibility. results: a total of 24 cases was reported. of these, 21 (87.5%) were females and 3 (12.5%) males. age varied from 18 to 46 years. a total of 43 eyes were damaged. the lesion was bilateral in 19 (79.2%) patients and in 5 (20.8%) it was unilateral. the initial visual acuity ranged from 20/20 to 20/70, and the final visual acuity was 20/25 or better in 40 (93%) eyes. of these, 33 (76.7%) eyes reached 20/20 or the last follow-up visit. only 2 (4.6%) eyes presented alteration in the sensibility to contrast and 3 (6.9%) remained with persistent scotoma. conclusion: this is the largest series of solar retinopathy after religious ritual. the cases herein presented showed a quite favorable evolution. however recovery of visual acuity is not complete, once scotoma and residual metamorphopsia persisted in a few patients.
Tratamento clínico da neurorretinite subaguda difusa unilateral com albendazol
Malaguido, Marcus Rudolph;Casella, Antonio Marcelo Barbante;Malaguido, Daniela Rossetto Garcia;
Arquivos Brasileiros de Oftalmologia , 2007, DOI: 10.1590/S0004-27492007000500016
Abstract: purpose: to describe the evolution of a series of cases of diffuse unilateral subacute neuroretinitis (dusn) treated with albendazole. methods: interventional case series. the authors developed a non-randomized clinical trial protocol to investigate the clinical evolution of diffuse unilateral subacute neuroretinitis cases treated with albendazole. according to protocol criteria up to now, six patients were selected that will be described separately. results: of the six studied patients, four presented the worm. all six patients treated with the antiparasitic drug showed improvement of visual acuity and of chorioretinal scars. during the weeks of treatment, evidence of worm inactivation was documented for the four patients with visible worms. no adverse drug side effects were observed. conclusions: the antiparasitic drug albendazole seems to be beneficial and safe in patients with diffuse unilateral subacute neuroretinitis. more studies are necessary to evaluate the effectiveness of albendazole in the treatment of diffuse unilateral subacute neuroretinitis.
Estudo experimental da inibi？？o da prolifera？？o vitreorretiniana pelo uso da hiperecina
Machado, Roberto Augusto Fernandes;Casella, Antonio Marcelo Barbante;Malaguido, Marcus Rudolph;Oguido, Ana Paula Miyagusko Taba;
Arquivos Brasileiros de Oftalmologia , 2009, DOI: 10.1590/S0004-27492009000500010
Abstract: purpose: to produce proliferative vitreoretinopathy (pvr) in an animal ocular trauma model. to evaluate the inhibition of (pvr) emergence and progression by hypericin. methods: experimental study. nineteen pigmented male adult rabbits weighing between 2,000 and 3,000 grams were used in this study. all of them were submitted to trauma model with dispase and retinal diathermy to induce pvr membranes formation. they were randomly assigned to receive hypericin (10 μm in 0.1 ml) or saline solution (0.1 ml) as placebo. they were evaluated clinically in the seventh, fourteenth, twenty-first and twenty-eighth postoperative days with indirect ophthalmoscopy and digital color retinography. the pvr degree was classified according to hida (0 to 7). results: membranes formation was present in 79% of the eyes; being 100% in the eyes of placebo group and 60% in the eyes of treatment group (hypericin). the comparison between pvr phases averages within the groups showed a statistically significant difference between the two groups, with a p value of 0.0321 for wilcoxon test. conclusions: the trauma model with dispase and retinal diathermy produces vitreoretinal membranes. hypericin was considered effective in pvr emergence and progression decrease.
Retinopatia solar após ritual religioso na cidade de Londrina
Sampaio Elaine Regina Ferraresi,Casella Antonio Marcelo Barbante,Farah Michel Eid
Arquivos Brasileiros de Oftalmologia , 2004,
Abstract: OBJETIVO: Relato de uma série de casos de retinopatia solar após a observa o direta do sol durante ritual religioso na cidade de Londrina. MéTODOS: 24 pacientes com altera o da vis o após participarem de ritual religioso, foram avaliados quanto à acuidade visual inicial e final, após 6 meses, refra o, biomicroscopia de mácula, retinografia, tela de Amsler e sensibilidade ao contraste. RESULTADOS: 24 casos foram relatados. Destes, 21 (87,5%) eram mulheres e 3 (12,5%) eram homens. A idade variou de 18 a 46 anos. Houve acometimento de 43 olhos. A les o foi bilateral em 19 (79,2%) pacientes e unilateral em 5 (20,8%). A acuidade visual inicial variou de 20/20 a 20/70 e a final foi de 20/25, ou melhor, em 40 (93%) olhos. Destes, 33 (76,7%) olhos alcan aram 20/20. Apenas 2 (4,6%) olhos ficaram com altera o da sensibilidade ao contraste e 3 (6,9%) ficaram com escotoma persistente. CONCLUS O: Este é o maior relato de casos de retinopatia solar após ritual religioso. A retinopatia solar apresenta evolu o bastante favorável. No entanto, a acuidade visual n o apresenta recupera o completa da vis o. Os pacientes podem ficar com escotoma e metamorfopsia residual.
Retinal nerve fiber layer atrophy as relevant feature for diffuse unilateral subacute neuroretinitis (DUSN): case series
Casella, Antonio Marcelo Barbante;Farah, Michel Eid;Souza, Eduardo Cunha de;Belfort Jr, Rubens;Oguido, Ana Paula Miyagusko Taba;
Arquivos Brasileiros de Oftalmologia , 2010, DOI: 10.1590/S0004-27492010000200017
Abstract: purpose: to report the findings of optical coherence tomography (oct) in three cases of diffuse unilateral subacute neuroretinitis (dusn). methods: three young patients with confirmed diagnosis of diffuse unilateral subacute neuroretinitis were followed-up using stratus？ oct. results: optical coherence tomography findings included retinal nerve fiber layer atrophy and focal edema where the worm was initially lodged. in two patients we could identify the worm by optical coherence tomography as an area of hiper-reflectivity. the worms were laser photocoagulated and post-treatment optical coherence tomography scanning revealed improvement of edema, nerve fiber layer thinning and a retinal hyper-reflectivity where laser had been applied. conclusion: the main finding reported here is the potential of optical coherence tomography in detecting the presence of retinal nerve fiber layer atrophy and focal retinal edema in areas affected by the worm. optical coherence tomography can be used to distinguish diffuse unilateral subacute neuroretinitis from other mimicking diseases like punctate outer retinitis, when there are no retinal fiber layer atrophy.
Angiografia: seguran？a x economia
Torres, Rogil José de Almeida;Muccioli, Cristina;Casella, Antonio Marcelo Barbante;Regonha, Eduardo;Luchini, Andréa;Weiss, Wilma;Frecceiro, Paulo Roberto;
Arquivos Brasileiros de Oftalmologia , 2006, DOI: 10.1590/S0004-27492006000600011
Abstract: purpose: to evaluate the safety, effectiveness, and cost of angiofluoresceinographic examination by using both the least amount of dye as well as digital equipment along with a laser photocopier. methods: prospective and comparative study carried out in a group of 70 patients, who underwent an angiographic evaluation with a conventional retinographer injecting 5 ml sodium fluorescein at 10% (control group) as well as a group of 70 patients who underwent an angiographic evaluation with a digital retinographer injecting 2 ml fluorescein at 10% (study group). arterial pressure, heart rate and oximetry were assessed prior to and after the dye injection. organic reactions related to the examination were reported. photograph quality as well as cost between the two techniques were compared. results: control group patients showed a greater increase in systolic and diastolic arterial pressure. heart rate, oximetry measurement and adverse reactions did not show any significant statistical differences between both groups. as for the quality of photographs, a better performance was noticed in the control group. as for the cost, the examination carried out in the study group required lower cost and thus saved around 54.8% per examination in relation to the control group. conclusion: the examination carried out with a lower dose of fluorescein using digital equipment along with a laser photocopier provided greater stability in the systolic and diastolic arterial pressure. however, it did not have any influence on heart rate, oximetry or adverse reactions such as nausea, vomiting, syncope and rashes. the quality of photographs was poor although they enabled diagnosis as well as therapy follow-up for those who carried out the examination. moreover, economically the above procedure represented a gain of 66.26%, against 25.81% in relation to the conventional equipment.
Prevalence of age-related macular degeneration in Japanese immigrants and their descendants living in Londrina (PR) - Brazil
Oguido, Ana Paula Miyagusko Taba;Casella, Antonio Marcelo Barbante;Matsuo, Tiemi;Ramos Filho, Eduardo Henrique de Freitas;Berbel, Rodrigo;Silva, Ricardo Montanheiro Alcantara;
Arquivos Brasileiros de Oftalmologia , 2008, DOI: 10.1590/S0004-27492008000300013
Abstract: purpose: to determine the prevalence of early and late-stage age-related macular degeneration (armd) and its association with risk factors such as age, gender, smoking, body mass index, hypertension and diabetes history, cataracts and pseudophakia. design: population-based cross-sectional study in an elderly japanese-brazilian population from londrina (paraná, brazil). methods: the study included 483 (80.5%) of the 600 registered members of a local association for japanese immigrants and their descendants, aged 60 years and up. the presence of early and late-stage age-related macular degeneration was determined using the standard protocol and the international classification system. results: the mean age of the study subjects was 71 years. the overall prevalence of age-related macular degeneration was 15.1% (ci 95%; 12-18.7). the prevalence of early-stage age-related macular degeneration was 13.8% (ci 95%; 10.9-17.3), geographic atrophy was present in 0.4% and neovascular age-related macular degeneration in 0.8%. age-related macular degeneration was significantly (p=0.004) and linearly (p=0.001) associated with age. conclusion: our study population displays a prevalence of early and late-stage age-related macular degeneration and component lesions similar to those of other western countries, and data suggest a higher prevalence than that reported for populations in japan. since the age-related macular degeneration prevalence tends to rise as the population ages, studies identifying risk factors and exploring prevention methods are becoming increasingly important.
Prevalência de acuidade visual reduzida nos alunos da primeira série do ensino fundamental das redes pública estadual e privada de Londrina-PR, no ano de 2000
Lopes, Gerson Jorge Aparecido;Casella, Ant？nio Marcelo Barbante;Chuí, Cristiane Assami;
Arquivos Brasileiros de Oftalmologia , 2002, DOI: 10.1590/S0004-27492002000600012
Abstract: purpose: to analyze the prevalence of reduced visual acuity in students of elementary state public and private schools of londrina's urban area; to compare the prevalence of reduced visual acuity in children of state public and private schools; to analyze and compare the prevalence of children wearing eye-glasses, and to describe the causes of reduced vision in this population. methods: the visual acuity test was performed in 1688 school children of state public schools and in 611 school children of private schools. the children with visual acuity 0.7 or worse in one of the eyes were directed to a ophthalmic examination. results: the reduced visual acuity prevalence in school children was 17.1% in state public schools, and 19.8% in private schools; this difference does not have statistical significance. the prevalence of children wearing eyeglasses was 2.4% in state public schools and 3.6% in private schools, without statistical significance between these results. the causes of reduced visual acuity were refractive errors, amblyopia, strabismus and other causes. conclusion: the prevalence of reduced visual acuity in students of elementary state public and private schools was statistically the same, as well as the prevalence of children wearing eyeglasses. the causes of reduced visual acuity were refractive errors, amblyopia, strabismus, congenital cataract aphakia, zonular congenital cataract, persistent of the hyperplastic primary vitreous, optic nerve atrophy and macular disorder.
Retinal detachment and gyrate atrophy of the choroid and retina: case report
Berbel, Rodrigo Fabri;Rauen, Paulo Igor;Pallone, Raphael Frangiote;Casella, Ant？nio Marcelo Barbante;
Arquivos Brasileiros de Oftalmologia , 2012, DOI: 10.1590/S0004-27492012000100012
Abstract: to report a case of gyrate atrophy of the choroid and retina associated with retinal detachment. hyperornithinemia confirmed the diagnosis of gyrate atrophy. pars plana vitrectomy with silicone oil infusion was performed with good anatomical results, despite the persistence of low visual acuity. retinal detachment is a rare complication of gyrate atrophy and can be managed with pars plana vitrectomy and silicone oil. we discuss the possible mechanisms that led to low visual acuity.
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